The Grand Prix de Denain is a French cycling race created in 1959 which takes place around the city of Denain in the Nord department.

The race is classified in category 1.1 from 2005 until 2015 by the UCI, then as a 1.HC until 2016 and is part of the French cyclism cup. In 2020, it joined the UCI ProSeries calendar.

In 2018, the course greatly evolves with the appearance of 12 cobbles sectors.

For this 2021 edition, 200,9 kilometers are on the clock.

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